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In a healthy, happy cell, NRF2 is kept in the cytoplasm by two proteins, Keap 1 and Collin 3

doi: 10.1634/theoncologist.2015-0502 127 CostaRSanta-MariaCAScholtensDMJainSFlaumLGradisharWJet al

In other words, the internal forward model serves as an internal feedback control

G., Kumar, S., Hitman, G
