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In the SURMOUNT-1 trial with 2,539 adults with obesity, participants on the highest tirzepatide dose (15 mg weekly) lost an average of 20.9% of their body weight over 72 weeks
It works intracellularly by inhibiting NNMT to preserve NAD+ and shift adipocyte metabolism a completely different mechanism, with different research read-outs
I., Sawek, J., Traykov, L., Ta Van, B., Vrkonyi, T., Reiners, K., & The Vitamin B Consensus Panelists Group (2024)
