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Construction of the Clinical Nomogram Application and Drug Targeting Based on LRG Signatures From the GSE21359 discovery dataset of the COPD patients and the control samples, a nomogram integrated with the expression levels of key genes CBR1 and PRDX1 was constructed to quantify their clinical utility in predicting COPD risk (Figure 5A)

Lysophosphatidylcholine acyltransferase 3 (LPCAT3) works synergistically with ACSL4, responsible for incorporating the PUFA-CoA activated by ACSL4 into membrane phospholipids, completing membrane remodeling