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Vitamin B12 plays a crucial role in this equation, especially for those with lower levels due to dietary choices or other health conditions
Moreover, cancer cells expressing mutant p53 exhibit increased sensitivity to mTOR inhibition compared to cancer cells with WT p53 [81]

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The results of this analysis also included greater mean AUEC, and shorter mean time to maximal response observed for the SC formulation compared to SL, while the incremental mean maximum response values for ascending doses of the two formulations were roughly comparable
