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We further observe that once heme moves inside the cavity toward the defined binding pocket, its interactions with R77 C , R81 C and R136 C become stronger while its interactions with the surface lysine groups diminish
In the context of liquid biopsy, biomarkers reflecting peripheral iron homeostasissuch as CSF ferritin and the serum sTfR/ferritin ratiohave demonstrated high sensitivity and specificity in distinguishing mild cognitive impairment (MCI) from AD (Du et al., 2024)
Medical history: A review of symptoms related to oxidative stress and immune system function
Lau et al., 2008)
