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Semaglutide, in particular, has garnered widespread use due to its remarkable results, helping patients lose an average of 15-20% of their body weight in clinical trials

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Despite the limitations of our lifespan data, findings from our cross-sectional studies in calorie-restricted mice provide robust evidence that glucagon receptor signaling is required for the healthspan benefits of CR and that glucagon receptor signaling at the liver is required for the CR-induced decrease in hepatic mTOR signaling, a primary driver of aging [17,18,19, 48, 97]