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Concomitant deficiencies (iron, folate), chronic illness, or drug interactions may blunt clinical response and warrant further evaluation

Research has shown that combinations of drug treatments, such as gabapentin or pregabalin with anti-inflammatory medications, can reduce pain more effectively and cause fewer side effects than using each drug alone (Vorobeychik et al., 2011)

Mechanistically, the triple-agonist design is a deliberate departure from the GLP-1-monoagonist (liraglutide, semaglutide) and GIP/GLP-1-dual-agonist (tirzepatide) classes