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In experimental systems, DSIP has been shown to influence second messenger activity and hormonal signaling cascades linked to the hypothalamicpituitaryadrenal axis, including regulation of adrenocorticotropic hormone and related endocrine mediators [4]

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direct oral supplementation with liothyronine therefore offers a rapid, predictable method of elevating serum T3 for patients whose endogenous conversion is inadequate or who require prompt replacement

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