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If mitochondria are uncoupled by breaking the membrane or by adding an uncoupler (a membrane-permeant weak acid that acts to transfer protons from outside to the matrix), then the ETC can work at its maximum rate (Fig

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Therefore, to trigger drug release at the cancerous tissue, a DDS can be manipulated to respond to an external stimulus (including heat, ultrasound, light, magnetic field) or an endogenous stimulus (including redox potential, pH, and unique enzymatic activity) in the TME 13,14,15,16

Cross-immunity and immune mimicry as mechanisms of resistance to the lantibiotic lacticin (3147)