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1 Several factors contribute to the decreased function of melanocytes, including genetic predispositions, ROS, nutritional deficiencies, autoimmune disorders, and environmental exposures

Similarly, intestinal Zip8 KO mice exhibit systemic Mn deficiency and aggravated colitis, which can be rescued by inhibition of the downstream sphingolipid enzyme ACER1 (Choi et al., 2024b)

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10.1016/j.ejphar.2007.05.072 141 TonoliniM.MagistrelliP
