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Although our findings primarily focus on the anti-inflammatory impact of Irisin on microglia and dopaminergic neurons, we recognize the potential significance of astrocyte modulation in Irisins protective mechanisms

chilense that contains the genes responsible for the phenotype was identified through genetic mapping (de Jong et al., 2004

Interestingly, in traumatic brain injury, GPx1 deficiency was associated with decreased mitochondrial bioenergetic capacity compared to wildtype mice, whereas transgenic GPx1 mice had no decrease in mitochondrial function [114] GPx1 deficiency also enhanced apoptosis and inflammation in a cold-induced brain injury model [115]

Alpha lipoic acid, which also has robust antioxidant activity , here may enhance these benefits when used in combination