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lactate is one of the major energy sources
Mirogabalin : Mirogabalin selectively binds to the 2-1 subunit of VGCCs, inhibiting overactive neurons
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The most emblematic example is bitopertin (RG1678), which initially demonstrated efficacy in phase II trials for schizophrenia negative symptoms yet failed to meet primary endpoints in multiple phase III trials (Umbricht et al
