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142 Additionally, inhibition of COX17 leads to elevated mitochondrial copper levels in leukemic stem cells, which results in reduced cellular levels of S-adenosylmethionine, subsequently decreasing global DNA methylation and increasing chromatin accessibility, which contributes to promoting the differentiation of acute myeloid leukemia cells while reducing stem cell-like characteristics

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The results presented in this paper indicate that the use of DMSO, even at the stage of sample preparation, should be seen as the introduction of an additional, external, independent factor capable of directly influencing the result obtained

Formation of 8-S-acetyldihydrolipoamide