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Most Americans get enough of this vitamin

Growth hormone, interleukin- (IL-1), and TNF- affect secretion of IGF-1whereas IGF-2 is affected by TNF- only
[11] It is less preferred than hydroxocobalamin for treating vitamin B 12 deficiency because it has a slightly lower bioavailability

When joint aches do occur temporally alongside B12 therapy, they are more likely coincidental or related to other factors rather than a direct pharmacological effect of the vitamin itself
