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In the classical model, Fe 2+ is involved in a variety of biochemical processes within the BCEC, including efflux

5.3 Overcoming the bloodbrain barrier (BBB): nanocarrier-based drug delivery The BBB severely restricts CNS penetration of most therapeutic agents

In this study, however, Pb levels were not discussed in the context of stored Pb levels in the bones and Pb levels in the bones were not assessed

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