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Aging is accompanied by deteriorating proteostasis and altered modification landscapes, which compromise the reversible and dynamic property of LLPS, triggering the formation of aberrant, solid-like aggregates that exacerbate neuronal dysfunction and neurodegeneration

Acknowledgements This research was supported by several grants: the KRIBB Research Initiative Program (KGM5242423), the Regional Innovation Strategy (RIS) program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education (MOE) (2021RIS-002), and the Basic Science Research Program through the NRF, funded by the Ministry of Education, Science, and Technology (No