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Description
The peptide demonstrates ability to reduce production of pro-inflammatory cytokines including tumor necrosis factor-alpha (TNF-) and interleukin-1 beta (IL-1), while promoting anti-inflammatory responses
sub-68 nm constructs favour renal elimination but limit loading, whereas larger constructs risk prolonged retention in the reticuloendothelial system and off-target oxidative injury
We also applied scaling to the NAD pool and synaptic glutamate release, which were literature-driven but had to be approximated, as we did not find exact numbers for their changes with aging
Tang D, Kang R
