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These analyses are then presented to the Ontario Health Technology Advisory Committee, whose mandate is to examine proposed health technologies in the context of available evidence and existing clinical practice, and to provide advice and recommendations to Ontario health care practitioners, the broader health care system, and the Ontario Ministry of Health and Long-Term Care

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Insulin Resistance (with prolonged use) Paradoxically, while IGF-1 LR3 acutely improves glucose uptake, chronic high-dose use can promote insulin resistance as a compensatory mechanism