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Although atropine can be addictive at higher concentrations, these studies were done over multiple years and found no long-term negative effects of low concentration atropine
mTORC1 inhibitors have been demonstrated to cause immune cells to switch from glycolysis to fatty acid oxidation, leading to improved metabolic adaptations and an extension of T-cell survival ( Furthermore, T cell function and depletion are caused by the upregulation of immune checkpoint receptor expression in AML patients and animal models (e.g., CTLA-4, PD-1, Tim-3)
