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PMID: 28728163

In fact, most of the patients with TDP-43 pathology do not have mutations in their TARDP gene, and yet have protein accumulations containing phosphorylated TDP-43 13 , and mostly ubiquitinated protein aggregates 10,14,15

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Pinocembrin can activate BNIP3-dependent mitophagy through the JNK-ERK pathway to exert neuroprotective function in IH models, inhibiting the formation of NLRP3 inflammasome [64], and NLRP3 deficiency was reported to protect against IH-mediated neuroinflammation and mitochondrial ROS [63]