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doi: 10.1016/j.bbrc.2006.12.119

This leads to cellular damage and inflammation, which contribute to diseases such as cardiovascular disorders (e.g., coronary artery disease, hypertension, and atherosclerosis), vascular diseases (e.g., rheumatoid arthritis and inflammatory bowel disease), neurodegenerative conditions (e.g., Alzheimers and Parkinsons diseases), respiratory disorders (e.g., asthma, acute lung injury, and cystic fibrosis), and cancer (Madamanchi et al., 2005

When circumventing responses to pathogenic infections such as coronaviruses, a healthy gut microbiome may be vital to maintain an optimal immune system, preventing a cascade of excessive immune responses that ultimately damage the lungs and vital organ systems (Figure 1)

In addition to the above mentioned, some lipid metabolites of AA are also known to contribute to high barrier permeability