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food and drug association FSP1: Ferroptosis suppressor protein 1 GCH1: GTP cyclohydrolase 1 Gly: Glycine GPX4: Glutathione peroxidase 4 GRT: Gene replacement therapy GSH: Glutathione reduced GSSG: Glutathione disulfide, oxidized His: Histidine IND: Investigational new drug iPSC: Induced pluripotent stem cell IRB: Institutional review board mGPX4: Mitochondrial GPX4 NAC: N-acetylcysteine NACA: N-acetylcysteine amide Nrf2: Nuclear factor erythroid 2-related factor 2 nGPX4: Nuclear GPX4 PHGPX: Phospholipid hydroperoxide glutathione peroxidase 4 PL: Phospholipid PL-OH: Phospholipid alcohol PL-OOH: Phospholipid hydroperoxide PL-PUFA: Phospholipid containing n-3 polyunsaturated fatty acids Pro: Proline ROS: Reactive oxygen species Sec: Selenocysteine SSMD: Sedaghatian type spondylometaphyseal dysplasia Tyr: Tyrosine Vit E: Vitamin E WES: Whole exome sequencing References Sedaghatian MR