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Description
In hypoxia reduced expression of EAAT1 and 2 contributes to increase extracellular glutamate concentration leading to neuronal overexcitation and excitotoxicity (Rossi et al., 2007
FSP1 was previously called flavoprotein apoptosis-inducing factor mitochondria-associated 2 (AIFM2)
doi: 10.3390/molecules23092401 138 WangPLiuYKangSYLyuCHanXHoTet al
They are phagocytosed by macrophages as foreign particles and recognized by Toll-like receptors 2 and 4 (TLR2/TLR4), which subsequently activate and oligomerize the NLRP3 complex
