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However, when the rats were IV injected 120 microg/kg of DSIP prior to being put in hypoxic conditions it was found that the stress-induced decrease in mitochondrial respiratory activity was completely eliminated

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METAOD006 was a 24-week, randomized, double-blind, placebo-controlled, multicenter Phase 2b study that enrolled around 500 clinically obese adults, randomized to daily oral doses of AOD-9604 (0.25, 0.5, or 1 mg) or placebo, on a background diet-and-exercise regimen