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[40] designed a nasal drug delivery system that utilized hesperidin-loaded chitosan nanoparticles (HPD/NPs) to target and manage lung inflammation and cytokine storm syndrome (CSS) in a mouse model of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), with potential applications for COVID-19 therapy

These results were confirmed in vitro in CRC cell lines observing reduced proliferation, cell survival, migration and invasion

[DOI] [PubMed] [Google Scholar] Guo J, Dai X, Xu W, Ma M

Of particular interest is that it is able to downregulate NADPH oxidase [399], thus preventing the transformation of EBV-infected cells by inhibiting the intracellular ROS production and DNA damage necessary for generating latency