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Betulinic Acid (BA), also known as birch acid, is a pentacyclic triterpenoid saponin widely distributed in the plant kingdom, extracted from the leaves of Syzygium cumini (L.) Skeels [Myrtaceae], Betula pendula Roth [Betulaceae], and Ziziphus jujuba Mill

There may even be levels of crosstalk and overlap between them that have not yet been fully elucidated but might have clinical relevance

Mechanistically, Src mediates both the transactivation of EGFR via MMP activity and the phosphorylation-dependent inactivation of PTEN, thereby sustaining PI3K/Akt signaling [55]

Wiernicki B, Dubois H, Tyurina YY, Hassannia B, Bayir H, Kagan VE, et al