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Description
Adequate vitamin B12 supports normal folate metabolism
Human clinical trial data remains limited, with Phase I and II trials for inflammatory bowel disease conducted in the 1990s claiming safety with no toxicity, though full peer-reviewed data never appeared in scientific literature
Intragastric and oral administration give detectable plasma levels for several hours in rodent studies, supported by the proline-rich sequence resisting cleavage by gastric proteases
Some evidence suggests that periodic breaks, 1 to 2 weeks off every 8 to 12 weeks, can reset receptor sensitivity
