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NAFLD progression seems to involve the occurrence of parallel, multiple-hit injuries, such as oxidative stress-induced mitochondrial dysfunction, endoplasmic reticulum stress, endotoxin-induced, TLR4-dependent release of inflammatory cytokines, and iron overload, among many others

The most striking result is the lower mtROS at 120 h, indicating that the initial increase in mtROS and subsequent increase in antioxidant enzyme activity ultimately lowered net mtROS production to a level lower than controls, which is the proposed explanation for the more than twofold increase in lifespan

Abstract Ubiquitously distributed multifunctional superfamily of Glutathione S -transferases (GST) generally constitute a dimeric enzymes and catalyse the conjugation of the thiol group of the glutathione (GSH) to diverse electrophilic centres on lipophilic molecules with the formation of rather less active end products

10.1021/jf405352g 14 ChenY.YeP.RenC.RenP.MaZ.ZhangL.et al (2018)