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10.3390/gels10080531 14 Al-MuthefferE

doi: 10.3389/fnmol.2023.1238453 115 GudiVkuljecJYildizFrichertKSkripuletzTMoharregh-KhiabaniDet al

a "co-stimulatory signal, as used herein, refers to a signal, that in combination with a primary signal, such as TCR/CD3 ligation, leads to T cell proliferation and/or upregulation or downregulation of key molecules

did note interactions between this system and antidepressant use