glutathione glutamine metabolism pathway metabolism: from proliferating cells to cardiomyocytes - Study proposes a new strategy

509 AS-252424 is a specific and targeted ACSL4 inhibitor that binds directly to the glutamine 464 of ACSL4 to inhibit its enzymatic activity, thereby inhibiting lipid peroxidation and ferroptosis, effectively alleviating ferroptosis-mediated organ damage in mouse models, including I/R-induced kidney injury and acute liver injury

Our findings that mitAspAT catalyzes a cysteine S -conjugate -lyase reaction with TFEC in vitro and is syncatalytically inactivated in the process (Cooper et al., 2002a) are consistent with the in vivo finding that this enzyme in the kidney is thioacylated after administration of TFEC to rats (Cooper et al., 2011)

doi: 10.15252/emmm.202216427 261 WallonC.YangP.-C.Keita

Three meta-analyses have been published on NAC administration in DILI