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Patients with inflammation of the joint are often excluded from cartilage repair attempts given that catabolic cytokines and proteinases (MMPs) present in the synovial fluid degrade the native ECM, and would similarly degrade any implanted tissue, predisposing treatment failure

The identified lipids spanned five major categories: fatty acyls, glycerolipids (GLs), glycerophospholipids (GPLs), sphingolipids (SPLs), and sterol lipids (STLs)

Furthermore, astrocytes regulate synaptic function by modulating synaptic transmission and plasticity, buffering extracellular K + , taking up neurotransmitters, and releasing gliotransmitters

10.1016/j.jcf.2014.08.008 41 CostelloC.Murphree-TerryM.OdenA.CombsS.KeithJ.BirketS