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NONCLINICAL TOXICOLOGY Carcinogenesis, Mutagenesis, Impairment of Fertility In a 2year study in Sprague-Dawley rats, albuterol sulfate caused a dose-related increase in the incidence of benign leiomyomas of the mesovarium at and above dietary doses of 2 mg/kg (approximately 15 times and 6 times the maximum recommended human daily inhalation dose (MRHDID) for adults and children, respectively, on a mg/m 2 basis)

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General maintenance typically requires a lower daily "top-off," whereas specific health challenges or aesthetic goals may require a more concentrated approach for a set period