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After loading, transition to maintenance dosing of 1000 mcg every 1 to 4 weeks depending on response and follow-up testing
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This approach has theoretical merit
Finally, in hepatocytes, PKD3 suppresses insulin-dependent a Ser/Thr Kinase (AKT) and mTORC1/2 activation, which results in peripheral glucose intolerance and suppression of hepatic lipid production (Mayer et al, 2019)
