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Increased blood concentration of homocysteine is another nonspecific biomarker of vitamin B 12 deficiency that has been linked to depressive symptoms in the elderly (108)

The nanocarrier strategy for crossing the blood-brain barrier in glioma therapy

It can lead to neuropathy, megaloblastic anemia, and pernicious anemia, [2] [13] causing symptoms including fatigue, paresthesia, depression, cognitive decline, ataxia, and even irreversible nerve damage