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Without these helper molecules (coenzymes), the enzymes will not work properly (or may not work at all) to catalyze reactions that lead to energy production

4,5 Dietary insufficiency, pernicious anemia (i.e., an autoimmune process that reduces available intrinsic factor and subsequent absorption of vitamin B 12 1,2,6,7 ), and long-term use of metformin or acid-suppressing medications have been implicated in B 12 deficiency

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