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CBDs PPAR-mediated inhibition of iNOS and NLRP3 in microglia implies it could reduce neuroinflammatory NO signaling in depression These studies confirm that CBD has antidepressant effects through various mechanisms, including reducing neuroinflammation driven by iNOS, enhancing anti-inflammatory signaling mediated by PPAR, and providing neuroprotective effects that alleviate depressive behaviors
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