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Carvalho, et Stefania Maggi

In this regard, the metabolic conversion of alcohol into acetaldehyde has been recognized as critically involved [32, 33], and this suggestion was further extended by the observation that another molecule, 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (salsolinol), obtainable by Pictet-Spengler condensation of acetaldehyde and DA, could be responsible for the reinforcing properties of alcohol and for its addictive potential [34, 35]

Additionally, chronic alcohol exposure decreases extrasynaptic GABA A -mediated tonic current recorded from neurons in the hippocampus and cortex (Liang et al., 2004

doi: 10.1016/j.cccn.2005.04.029 50 Soetekouw PMWRVrekenPElvingLDJanssenAJvan der VeenYBleijenbergGet al