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A1AT can impair neutrophil migration towards inflamed tissues through two different mechanisms, affecting both IL-8-induced chemotaxis and chemotaxis induced by soluble immune complexes (sIC) (35)

10.1038/nn.3584 306 RentonA

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In endosomes, ferric iron (Fe 3+ ) is reduced to Fe 2+ by STEAP3 and subsequently transported to lysosomes via DMT1, eventually saturating intracellular iron storage capacity
