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The mechanism appears to involve increased serotonin synthesis in substantia nigra (both compacta and reticulata), a regional pattern unlike any existing antidepressant drug, plus potential dopaminergic contributions given the nigrostriatal location

The information presented here reflects the consensus emerging from user communities, peptide researchers, and practitioners familiar with these compounds

Journal (Journal of Physiology and Pharmacology, Dec 2009, 60 Suppl 7, 191196)

But the weight gain is not a direct result of the deficiency but rather an indirect result
