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The human ULK1 protein functions similarly to the yeast ATG1 protein
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Patients with normal or high-normal IGF-1 levels for their age group may not be appropriate candidates, as further GH stimulation in these individuals carries a different risk-benefit profile than in patients with documented decline

The -syn protofibrils can form pore-like assemblies on the membranes of intracellular vesicles to impair vesicle integrity, leading to leakage of vesicle contents and dopaminergic neuron vulnerability [125]