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There is a complex and multifactorial pathophysiology involved here

Clin Biochem 20:17 Schuck PF, da Costa Ferreira G, Tahara EB, Klamt F, Kowaltowski AJ, Wajner M (2010) cis-4-decenoic acid provokes mitochondrial bioenergetic dysfunction in rat brain

The ability to incorporate drugs into nanocarriers offers a new prototype in drug delivery that could hold great promise for attaining bioavailability enhancement along with controlled and site-specific drug delivery