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These changes in the mature adipocytes defining characteristics compromise the models physiological relevance and prevent the ceiling culture technique from accurately replicating lipedema pathology over long-term culture
Am J Hum Genet 82: 333343 [DOI] [PMC free article] [PubMed] [Google Scholar] Rebelo AP, Dillon LM, Moraes CT 2011
Several studies concluded that Met amplification is a predictor for efficacy of Met-targeted therapies (50)
Environmental factors, including exposure to carcinogens and fluctuations in hormonal or metabolic pathways, may also play a role
