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These 13 included five of the 12 individuals in the 3.0 g/d group, and seven of the 14 participants in the 4.5 g/d group but only one individual in the 1.5 g/d group reported leg pump as a limiting factor

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Basic research indicates that both PPAR and PGC1 stimulate CPT1A transcription by binding distinct regulatory regions within the CPT1A promoter (52)