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There are several additional small molecules, such as l-cysteine, l-tyrosine, albumin or ferritin, which prevent Fenton reaction-derived ROS and possess antioxidant potential [20]

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Concerning CYP1A2, in vivo induction is suggested, as demonstrated by the paraxanthine-to-caffeine ratio rising in healthy subjects ( In light of these findings, the safety and efficacy profile of RIF during TB treatment can be altered in smokers because of the concomitant induction of CYP450 enzymes mediated by PAHs