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Finally, targeted modulation of NFB and STAT3 pathways may offer selective protection against neuro-inflammation in dementia, for example using natural and rationally-designed inhibitors of the NFB pathway (as reviewed, Srinivasan and Lahiri, 2015) and small molecule STAT3 inhibitors which are effective in cancer models (Fletcher et al., 2011)

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Understanding how these mechanisms adapt to varying metabolic and signaling states within cells will enhance our understanding of the pathophysiological events underlying neurological diseases, particularly in identifying new biomarkers and potential pharmacological targets
