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Figure 4 Figure 5 5 Therapeutic strategies targeting energy metabolism in TMJ disorders The treatment of TMD generally falls into two primary categories: pharmacological management, particularly for inflammatory osteoarthropathies and autoimmune conditions such as rheumatoid arthritis, and surgical interventions, especially in cases involving abnormalities in TMJ energy metabolism and joint degeneration

Iron exhibits redox activity and engages in the production of intracellular free radicals and lipid peroxides ( via the Fenton reaction, which means reactions of Fe 2+ and peroxides to generate oxygen-centered radicals (Winterbourn, 1995)

RAI works by getting into overactive thyroid cells and destroying enough thyroid tissue to lower thyroid hormone levels [16, 4]

It can lead to memory loss and signs of dementia, especially in older adults