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Hyperhomocysteinemic subjects also had raised serum levels of MMP-9 comparing healthy controls, and although IL-10 markedly suppressed MMP-9 release from PBMCs in controls, no or only minor effect was seen in hyperhomocysteinemic subjects [91]

10.1016/j.lfs.2015.11.021 98 RivoltaI.BindaA.MasiA.DiFrancescoJ

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Several studies conducted with higher doses of sulforaphane in mice do describe toxicities that require careful attention to risk-benefit analyses and determination of therapeutic or prophylactic indices