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[0585] In certain embodiments methods of cellular therapy are provided where the cellular therapy utilizes cells (e.g., immunomodulatory cells such as T cells) genetically modified to express a CAR as described herein and the CAR expressing cell (e.g., CAR T cell) is infused to a recipient in need thereof

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Once reduced, excess cysteine is then exported to the extracellular medium, mediated by the broad spectrum amino acid exporter AlaE (Korshunov et al., 2020) (Fig

We next trained algorithms predicting TMAO using the 24 variables identified by our SHAP analysis (top SHAP model) and compared it to models trained by traditional clinical risk factors 31 or the full model (Fig