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In addition to its economic importance, nicotine functions as a defensive secondary metabolite that protects tobacco plants against herbivorous insects and other environmental stresses 2

Peroxynitrite mediates neurotoxicity of amyloid -peptide142- and lipopolysaccharide-activated microglia

Predictive coding is a proposed model that may conceptually explain the recruitment of attentional centers in the pathophysiology of tinnitus (182)

Some studies report modest reductions in postprandial glucose and improvements in insulin sensitivity, potentially mediated by glucagon-like peptide-1 modulation and gut microbiota interactions, although these mechanisms remain preliminary and not fully established clinically
