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Braz J Biol 84:e285332
doi: 10.1016/S0140-6736(08)61620-7 11 ConstantinescuC
Probiotics and the gut immune system: indirect regulation
PDK1 knockout reduced the phosphorylation level of PDHE1 and upregulated the activity of PDHC, thus inhibiting LPS-induced anaerobic glycolysis and the polarization of macrophages from an M2 to an M1 phenotype and, consequently, reducing the levels of the inflammatory mediators interleukin (IL)-6, IL-12, and IL-1
